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KMID : 0380620180500040451
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Korean Journal of Food Science and Technology
2018 Volume.50 No. 4 p.451 ~ p.456
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Anti-cancer effect of Sarijang on colorectal cancer cells in a xenograft nude mouse model
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Lee Tae-Hee
Song Hyun-Kyung
Kim Dong-Yoon
Lee Isaac
Seo Hyeong-Ho
Choi Ji-Young
Kim Hong-Geun
Choi Eun-A
Han Beom-Seok
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Abstract
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The current study was conducted to confirm the anti-cancer effect of Sarijang, which is a mixture of extracts from purple bamboo salt, Rhynchosia nulubilis, garlic, and Ulmi cortex. Nude mice were injected with a human-derived colorectal cancer cell (HCT116 cell line) and subsequently administered Sarijang for 4 weeks, following which the body weight, organ weight, and tumor size were measured. To evaluate the anti-cancer mechanism of Sarijang, the levels of p-16 and extracellular signal-regulated kinase (ERK), cell cycle regulators in colorectal cancer, were measured. To evaluate the toxicity of Sarijang on liver and kidney, aspartate transaminase, alanine transaminase, blood urea nitrogen, and creatinine were analyzed. Sarijang not only reduced the tumor size by enhancing p16 and suppressing ERK, but also showed no side-effect in the liver and kidneys. Taken together, Sarijang has the potential to inhibit tumor growth without side effects, and may be used as a useful functional food.
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KEYWORD
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colorectal cancer, cell cycle, xenograft, Sarijang, ERK
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